Frédéric Gibou's research is focused on the design and the applications of new high resolution multi-scale computational algorithms for a variety of applications including materials science, multiphase flows at the micro/nanoscale, computer vision with an emphasis on the segmentation of medical images and computer graphics. Together with colleagues at the Greenscale Center for Energy–Efficient Computing, he applies his research interests to developing specialized architectures to calibrate reduced-order models of airflow in supercomputers.